Kasperi Kapanen, Vasily Podkolzin and Brett Kulak additionally scored as Edmonton gained for the fourth time in 5 video games.
Nikolai Kovalenko scored for Colorado, and Alexandar Georgiev had 28 saves.
Kovalenko had a power-play aim at 7:02 of the primary interval because the Avalanche went 1 for five with the person benefit.
Kapanen, enjoying his fourth recreation with the Oilers since being claimed off waivers on Nov. 19, tied it lower than 5 minutes later. Connor McDavid introduced the puck across the internet, attracted the eye of a lot of the Colorado defence and hit an open Kapanen with a backhanded, cross-crease cross for his nineteenth help of the season.
Podkolzin put the Oilers forward for good with 6:12 left within the second interval. Troy Stecher had an help on the play, extending his streak to 3 video games.
Kulak made it 3-1 at 3:56 of the third and Nugent-Hopkins added an empty-netter with 1:32 to go.
Avalanche: Samuel Girard, enjoying in his five hundredth profession recreation, had an help on Kovalenko’s aim, tying Erik Johnson for sixth in franchise historical past with 178 assists
Oilers: Edmonton improved to 3-11-1 of their final 15 conferences with the Avalanche, together with the playoffs. It additionally ended a six-game dropping streak (0-5-1) within the common season in Colorado.
Podkolzin’s aim proved to be the successful aim and strengthened the Oilers’ grip on a recreation they largely managed after the opening 10 minutes of the primary interval.
McDavid’s help gave him 34 factors (14 objectives, 20 assists) in 22 profession video games towards the Avalanche.
Avalanche go to Buffalo on Tuesday, and Oilers go to Vegas.